WRN suppresses p53/PUMA-induced apoptosis in colorectal cancer with microsatellite instability/mismatch repair deficiency

Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2219963120. doi: 10.1073/pnas.2219963120. Epub 2023 Jan 4.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Apoptosis
  • Apoptosis Regulatory Proteins
  • Colorectal Neoplasms* / genetics
  • DNA Mismatch Repair
  • Humans
  • Microsatellite Instability*
  • Microsatellite Repeats
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • Werner Syndrome Helicase / genetics

Substances

  • Apoptosis Regulatory Proteins
  • Tumor Suppressor Protein p53
  • Werner Syndrome Helicase
  • WRN protein, human
  • Proto-Oncogene Proteins

Supplementary concepts

  • Turcot syndrome