Update in Human Immunodeficiency Virus and Aging

Jason R Faulhaber; Anthony W Baffoe-Bonnie; Krisann K Oursler; Shikha S Vasudeva

doi:10.1016/j.idc.2022.11.006

Update in Human Immunodeficiency Virus and Aging

Infect Dis Clin North Am. 2023 Mar;37(1):153-173. doi: 10.1016/j.idc.2022.11.006.

Authors

Jason R Faulhaber¹, Anthony W Baffoe-Bonnie², Krisann K Oursler³, Shikha S Vasudeva³

Affiliations

¹ Virginia Tech Carilion School of Medicine, Carilion Clinic, Division of Infectious Diseases, 213 McClanahan St SW, Roanoke, VA 24014, USA. Electronic address: jrfaulhaber@carilionclininc.org.
² Virginia Tech Carilion School of Medicine, Carilion Clinic, Division of Infectious Diseases, 213 McClanahan St SW, Roanoke, VA 24014, USA.
³ Virginia Tech Carilion School of Medicine, VA Salem Healthcare System, 1970 Roanoke Boulevard Salem, VA 24153-6404, USA.

PMID: 36805011
DOI: 10.1016/j.idc.2022.11.006

Abstract

Effective and consistent antiretroviral therapy has enabled people with human immunodeficiency virus (HIV) (PWH) to survive longer than previously encountered earlier in the epidemic. Consequently, PWH are subject to the struggles and clinical conditions typically associated with aging. However, the aging process in PWH is not the same as for those who do not have HIV. There is a complex interplay of molecular, microbiologic, and pharmacologic factors that leads to accelerated aging in PWH; this leads to increased risk for certain age-related comorbidities requiring greater vigilance and interventions in routine care.

Keywords: Aging; Antiretroviral therapy; HIV.

Publication types

Review

MeSH terms

Aging
Comorbidity
HIV Infections* / complications
HIV Infections* / drug therapy
HIV Infections* / epidemiology
HIV*
Humans