Case report: Xenotransfusion of canine lyophilized platelets for hemostasis in a feline patient with post-operative abdominal hemorrhage

Elizabeth Mannucci; April Blong; Chelsea Zorn; Rebecca Walton

doi:10.3389/fvets.2023.1113846

Case report: Xenotransfusion of canine lyophilized platelets for hemostasis in a feline patient with post-operative abdominal hemorrhage

Front Vet Sci. 2023 Feb 7:10:1113846. doi: 10.3389/fvets.2023.1113846. eCollection 2023.

Authors

Elizabeth Mannucci¹, April Blong², Chelsea Zorn², Rebecca Walton^{1

2}

Affiliations

¹ Emergency and Critical Care Department, VCA West Los Angeles Animal Hospital, Los Angeles, CA, United States.
² Department of Clinical Sciences, Iowa State University, Ames, IA, United States.

Abstract

Objective: To describe the management of post-operative abdominal hemorrhage with a xenotransfusion of canine lyophilized platelets in a feline patient.

Case summary: A 9-year-old male castrated domestic shorthair presented for a spontaneous hemoabdomen secondary to hepatic amyloidosis. Clinically significant hemorrhage occurred in the perioperative and post-operative period and the patient received a massive transfusion and anti-fibrinolytic therapy in combination with a xenotransfusion of canine lyophilized platelets at 0.9 × 10⁹ particles/kg and recombinant human factor VIIa (rhFVIIa). The combination of these interventions decreased transfusion requirements in this patient and the xenotransfusion was well tolerated with no acute or immediate transfusion reactions noted.

New or unique information provided: This case report describes the xenotransfusion of canine lyophilized platelets in a feline patient with severe, non-compressible abdominal hemorrhage.

Keywords: hemorrhage; platelets; thrombocytopenia; transfusions; xenotransfusion.

Publication types

Case Reports