Cerebral Venous Sinus Thrombosis Following an mRNA COVID-19 Vaccination and Recent Oral Contraceptive Use

Timothy C Frommeyer; Tongfan Wu; Michael M Gilbert; Garrett V Brittain; Stephen P Fuqua

doi:10.3390/life13020464

Cerebral Venous Sinus Thrombosis Following an mRNA COVID-19 Vaccination and Recent Oral Contraceptive Use

Life (Basel). 2023 Feb 7;13(2):464. doi: 10.3390/life13020464.

Authors

Timothy C Frommeyer¹, Tongfan Wu¹, Michael M Gilbert¹, Garrett V Brittain¹, Stephen P Fuqua²

Affiliations

¹ Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
² Department of Neurology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.

Abstract

Rising concerns of cerebral venous sinus thrombosis (CVST) and other forms of venous thromboembolism have been associated with the SARS-CoV-2 vaccinations. Adverse effects with vector-based vaccines are well documented in the literature, while less is known about the mRNA vaccines. This report documents a case of CVST in a 32-year-old female patient who received her second Pfizer mRNA COVID-19 vaccination 16 days prior to hospital admission and had started oral combined contraceptives approximately 4 months beforehand. Clinicians should be cognizant of the possibility that mRNA vaccines, when combined with other risk factors like oral contraceptive pill use, may enhance one's hypercoagulable status.

Keywords: COVID-19; cerebral venous thrombosis; mRNA; oral contraception; vaccination.

Publication types

Case Reports

Grants and funding

This research was funded in part by an unrestricted grant from the Wright State University Department of Pharmacology and Toxicology.