AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research

Hallvard Lauritz Olsvik; Terje Johansen

doi:10.1371/journal.pbio.3002002

AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research

PLoS Biol. 2023 Feb 8;21(2):e3002002. doi: 10.1371/journal.pbio.3002002. eCollection 2023 Feb.

Authors

Hallvard Lauritz Olsvik¹, Terje Johansen¹

Affiliation

¹ Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.

Abstract

In this issue of PLOS Biology, Ibrahim and colleagues demonstrate how AlphaFold-multimer, an artificial intelligence-based structure prediction tool, can be used to identify sequence motifs binding to the ATG8 family of proteins central to autophagy.

Copyright: © 2023 Olsvik, Johansen. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication types

Comment

MeSH terms

Artificial Intelligence*
Autophagy*
Protein Binding
Protein Domains

Grants and funding

TJ's research is funded by the Research Council of Norway (grant 249884) and the Norwegian Cancer Society (grant 190214). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.