The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent

Abstract

Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actual burden of DCM in this region are still lacking. Also, little is known about the genetic basis of DCM in this population, and genetic testing is still not readily accessible. This review describes the common pathogenic genes implicated in DCM globally and discusses the evidence-based management of patients with DCM. We also present a summary of studies describing genes implicated or associated with DCM in patients residing in SSA.

Keywords: Familial dilated cardiomyopathy; Genetics; Heart failure; Idiopathic dilated cardiomyopathy; Monogenic; Sub-Saharan Africa.