A massive machine regulates cell death

Science. 2023 Mar 17;379(6637):1093-1094. doi: 10.1126/science.adg9605. Epub 2023 Mar 16.

Authors

Peter D Mace¹, Catherine L Day¹

Affiliation

¹ Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.

PMID: 36927032
DOI: 10.1126/science.adg9605

Abstract

Structural analysis reveals how the decision to induce apoptotic cell death is regulated.

MeSH terms

Apoptosis*
Caspases / metabolism
Enzyme Activation
Humans
Inhibitor of Apoptosis Proteins* / chemistry
Inhibitor of Apoptosis Proteins* / metabolism

Substances

BIRC6 protein, human
Inhibitor of Apoptosis Proteins
Caspases