Effective immunotherapy occurs in neurons

Science. 2023 Mar 31;379(6639):1300-1301. doi: 10.1126/science.adg9800. Epub 2023 Mar 30.

Author

Rebecca M Nisbet¹

Affiliation

¹ Florey Institute of Neuroscience and Mental Health The University of Melbourne, Parkville, Melbourne, Australia.

PMID: 36996197
DOI: 10.1126/science.adg9800

Abstract

Neuronal clearance of proteins in the brain proves to be important for immunotherapy.

MeSH terms

Animals
Antibodies, Monoclonal* / therapeutic use
Brain* / immunology
Brain* / pathology
Humans
Immunotherapy*
Mice
Neurons* / immunology
Neurons* / pathology
Tauopathies* / therapy
tau Proteins* / antagonists & inhibitors
tau Proteins* / immunology

Substances

tau Proteins
Antibodies, Monoclonal