Cancer immunotherapy: T cells and neutrophils working together to attack cancers

Ann Ager

doi:10.1016/j.cell.2023.03.005

Cancer immunotherapy: T cells and neutrophils working together to attack cancers

Cell. 2023 Mar 30;186(7):1304-1306. doi: 10.1016/j.cell.2023.03.005.

Author

Ann Ager¹

Affiliation

¹ Division of Infection and Immunity, Systems Immunity University Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK. Electronic address: agera@cardiff.ac.uk.

PMID: 37001496
DOI: 10.1016/j.cell.2023.03.005

Abstract

The discovery of immune checkpoint inhibitors that boost T cell activity has revolutionized cancer treatment. However, these therapies do not work in all patients, and the quest is on to understand why. Two new studies published in this issue of Cell reveal the surprising finding that activated T cells can recruit neutrophils to kill cancer cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Immunotherapy
Neoplasms* / therapy
Neutrophils*
T-Lymphocytes

Abstract

Publication types

MeSH terms

Grants and funding