Social Determinants of Health and Mortality After Premature and Non-premature Acute Coronary Syndrome

Sagar B Dugani; Mohammad Zubaid; Wafa Rashed; Marlene E Girardo; Zuhur Balayah; Samia Mora; Alawi A Alsheikh-Ali

doi:10.1016/j.mayocpiqo.2023.03.002

Social Determinants of Health and Mortality After Premature and Non-premature Acute Coronary Syndrome

Mayo Clin Proc Innov Qual Outcomes. 2023 Apr 22;7(3):153-164. doi: 10.1016/j.mayocpiqo.2023.03.002. eCollection 2023 Jun.

Authors

Sagar B Dugani¹, Mohammad Zubaid², Wafa Rashed³, Marlene E Girardo⁴, Zuhur Balayah⁵, Samia Mora⁶, Alawi A Alsheikh-Ali⁷

Affiliations

¹ Division of Hospital Internal Medicine and Division of Health Care Delivery Research, Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
² Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
³ Division of Cardiology, Mubarak Al Kabeer Hospital, Kuwait University, Kuwait.
⁴ Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ.
⁵ Bayes Business School, Centre for Health Care Innovation Research, University of London, UK.
⁶ Center for Lipid Metabolomics, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
⁷ College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Abstract

Objective: To describe and compare the determinants of 1-year mortality after premature vs non-premature acute coronary syndrome (ACS).

Patients and methods: Participants presenting with ACS were enrolled in a prospective registry of 29 hospitals in 4 countries, from January 22, 2012 to January 22, 2013, with 1-year of follow-up data. The primary outcome was all-cause 1-year mortality after premature ACS (men aged <55 years and women aged <65 years) and non-premature ACS (men aged ≥55 years and women aged ≥65 years). The associations between the baseline patient characteristics and 1-year mortality were analyzed in models adjusting for the Global Registry of Acute Coronary Events (GRACE) score and reported as adjusted odds ratio (aOR) (95% CI).

Results: Of the 3868 patients, 43.3% presented with premature ACS that was associated with lower 1-year mortality (5.7%) than those with non-premature ACS. In adjusted models, women experienced higher mortality than men after premature (aOR, 2.14 [1.37-3.41]) vs non-premature ACS (aOR, 1.28 [0.99-1.65]) (P _interaction=.047). Patients lacking formal education vs any education had higher mortality after both premature (aOR, 2.92 [1.87-4.61]) and non-premature ACS (aOR, 1.78 [1.36-2.34]) (P _interaction=.06). Lack of employment vs any employment was associated with approximately 3-fold higher mortality after premature and non-premature ACS (P _interaction=.72). Using stepwise logistic regression to predict 1-year mortality, a model with GRACE risk score and 4 characteristics (education, employment, body mass index [kg/m²], and statin use within 24 hours after admission) had higher discrimination than the GRACE risk score alone (area under the curve, 0.800 vs 0.773; P _comparison=.003).

Conclusion: In this study, women, compared with men, had higher 1-year mortality after premature ACS. The social determinants of health (no formal education or employment) were strongly associated with higher 1-year mortality after premature and non-premature ACS, improved mortality prediction, and should be routinely considered in risk assessment after ACS.

Abstract

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