HIV-Related Atherosclerosis: State-of-the-Art-Review

Ashot Avagimyan; Nana Pogosova; Lev Kakturskiy; Mohammad Sheibani; Olga Urazova; Artem Trofimenko; Grizelda Navarsdyan; Zinaida Jndoyan; Kristina Abgaryan; Federica Fogacci; Mattia Galli; Luciano Agati; Zhanna Kobalava; Davood Shafie; Mario Marzilli; Liana Gogiashvili; Nizal Sarrafzadegan

doi:10.1016/j.cpcardiol.2023.101783

HIV-Related Atherosclerosis: State-of-the-Art-Review

Curr Probl Cardiol. 2023 Sep;48(9):101783. doi: 10.1016/j.cpcardiol.2023.101783. Epub 2023 May 11.

Authors

Ashot Avagimyan¹, Nana Pogosova², Lev Kakturskiy³, Mohammad Sheibani⁴, Olga Urazova⁵, Artem Trofimenko⁶, Grizelda Navarsdyan⁷, Zinaida Jndoyan⁸, Kristina Abgaryan⁹, Federica Fogacci¹⁰, Mattia Galli¹¹, Luciano Agati¹², Zhanna Kobalava¹³, Davood Shafie¹⁴, Mario Marzilli¹⁵, Liana Gogiashvili¹⁶, Nizal Sarrafzadegan¹⁷

Affiliations

¹ Assistant Professor, Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia. Electronic address: dr.ashotavagimyan@gmail.com.
² Professor, Deputy of General Director for Science and Preventive Cardiology, National Medical Research Centre of Cardiology after E. Chazov, Moscow, Russia.
³ Professor, Scientific Director, Research Institute of Human Morphology FSBI «Petrovskiy NRCS, Moscow, Russia.
⁴ Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Razi Drug Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁵ Professor, Head of Pathophysiology Department, Siberian State Medical University, Tomsk, Russia.
⁶ Associate Professor, Pathophysiology Department, Kuban State Medical University, Krasnodar, Russia.
⁷ Professor, Pathophysiology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia.
⁸ Professor, Head of Internal Diseases Propedeutics Department, Yerevan State Medical University after M. Heratsi, Armenia.
⁹ Associate Professor, Medical Microbiology Department, Yerevan State Medical University after M.Heratsi, Armenia.
¹⁰ Research Fellow, Atherosclerosis and Metabolic Disorders Research Unit, University of Bologna, Bologna, Italy.
¹¹ Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.
¹² Professor of Cardiology Department, Head of Cardiology Unit Azienda Policlinico Umberto II, Sapienza University, Rome, Italy.
¹³ Professor, Head of Internal Disease, Cardiology and Clinical Pharmacology Department, Peoples' Friendship University of Russia (RUDN), Moscow, Russia.
¹⁴ Isfahan Cardiovascular Research Institute, Isfahan, Iran.
¹⁵ Professor, Head of Cardiovascular Medicine Division, University of Pisa, Pisa, Italy.
¹⁶ Professor, Head of Experimental and Clinical Pathology Department, Al. Natishvili Institute of Experimental Morphology, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia.
¹⁷ Professor, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 37172874
DOI: 10.1016/j.cpcardiol.2023.101783

Abstract

The infection caused by the Human Immunodeficiency Virus (HIV) has spread rapidly across the globe, assuming the characteristics of an epidemic in some regions. Thanks to the introduction of antiretroviral therapy into routine clinical practice, there was a considerable breakthrough in the treatment of HIV, that is now HIV is potentially well-controlled even in low-income countries. To date, HIV infection has moved from the group of life-threatening conditions to the group of chronic and well controlled ones and the quality of life and life expectancy of HIV⁺ people, with an undetectable viral load is closer to that of an HIV^- people. However, unsolved issues still persist. For example: people living with HIV are more prone to the age-related diseases, especially atherosclerosis. For this reason, a better understanding of the mechanisms of HIV-associated destabilization of vascular homeostasis seems to be an urgent duty, that may lead to the development of new protocols, bringing the possibilities of pathogenetic therapies to a new level. The purpose of the article was to evaluate the pathological aspects of HIV-induced atherosclerosis.

Publication types

Review

MeSH terms

Antiretroviral Therapy, Highly Active
HIV Infections* / complications
HIV Infections* / drug therapy
HIV Infections* / epidemiology
HIV*
Humans
Quality of Life