The Management of Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With Biologics

A Wautlet; C Bachert; M Desrosiers; Peter W Hellings; Anju T Peters

doi:10.1016/j.jaip.2023.04.054

The Management of Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With Biologics

J Allergy Clin Immunol Pract. 2023 Sep;11(9):2642-2651. doi: 10.1016/j.jaip.2023.04.054. Epub 2023 May 12.

Authors

A Wautlet¹, C Bachert², M Desrosiers³, Peter W Hellings⁴, Anju T Peters⁵

Affiliations

¹ Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
² Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Munster, Munster, Germany; Department of Otorhinolaryngology, First Affiliated Hospital, Sun Yat-Sen University, International Airway Research Center, Guangzhou, China; Upper Airways Research Laboratory, Department of Otorhinolaryngology, Faculty of Medicine, Ghent University, Ghent, Belgium.
³ Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
⁴ Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium; Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, Ghent, Belgium.
⁵ Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: anjupeters@northwestern.edu.

PMID: 37182568
DOI: 10.1016/j.jaip.2023.04.054

Abstract

Chronic rhinosinusitis with nasal polyps affects a significant portion of the worldwide population. This illness is associated with several chronic conditions and has an important impact on patient quality of life, leading to a great societal economic burden. In recent years, biologic medications have been developed and found to be effective in the treatment of chronic rhinosinusitis with nasal polyps. This review focuses on these treatment options and their ability to improve patient outcomes, including quality of life. It also reviews available evidence with regards to patient selection, monitoring of patients after treatment initiation, and comparison of different biologics and with other treatment options such as sinus surgery.

Keywords: Biologics; Chronic rhinosinusitis; Nasal polyps.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biological Products* / therapeutic use
Chronic Disease
Humans
Nasal Polyps* / epidemiology
Quality of Life
Rhinitis* / epidemiology
Sinusitis* / epidemiology

Substances

Biological Products

Grants and funding

P01 AI145818/AI/NIAID NIH HHS/United States