Pediatric combined living donor liver and kidney transplantation for primary hyperoxaluria type 2

Abstract

We report the case of a 12-year-old boy with primary hyperoxaluria type 2 (PH2) presenting with end-stage renal disease and systemic oxalosis who underwent a combined living donor liver and kidney transplant from 3 donors, 1 of whom was a heterozygous carrier of the mutation. Plasma oxalate and creatinine levels normalized immediately following the transplant and remain normal after 18 months. We recommend combined liver and kidney transplantation as the preferred therapeutic option for children with primary hyperoxaluria type 2 with early-onset end-stage renal disease.

Keywords: combined liver and kidney transplant; end-stage renal disease; hypothyroidism; oxalosis; pediatric; primary hyperoxaluria; primary hyperoxaluria type 2.