Toward a standard model for autophagosome biogenesis

Annan S I Cook; James H Hurley

doi:10.1083/jcb.202304011

Toward a standard model for autophagosome biogenesis

J Cell Biol. 2023 Jul 3;222(7):e202304011. doi: 10.1083/jcb.202304011. Epub 2023 Jun 5.

Authors

Annan S I Cook^{1

2

3}, James H Hurley^{1

2

3

4

5}

Affiliations

¹ Graduate Group in Biophysics, University of California, Berkeley , Berkeley, CA, USA.
² California Institute for Quantitative Biosciences, University of California, Berkeley , Berkeley, CA, USA.
³ Aligning Science Across Parkinson's (ASAP) Collaborative Research Network , Chevy Chase, MD, USA.
⁴ Department of Molecular and Cell Biology, University of California, Berkeley , Berkeley, CA, USA.
⁵ Helen Wills Neuroscience Institute, University of California, Berkeley , Berkeley, CA, USA.

Abstract

Two papers in this issue resolve a long-standing obstacle to a "standard model" for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome component, while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle tracking to show that the dynamics of autophagy proteins are consistent with the concept.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Autophagosomes*
Autophagy*
Autophagy-Related Proteins*
Macroautophagy
Mammals

Substances

Autophagy-Related Proteins

Grants and funding

T32 GM008295/GM/NIGMS NIH HHS/United States