Metabolism: How a eukaryote adapted to life without respiration

Lloyd Cool; Samuel Hanon; Kevin J Verstrepen

doi:10.1016/j.cub.2023.05.002

Metabolism: How a eukaryote adapted to life without respiration

Curr Biol. 2023 Jun 5;33(11):R444-R447. doi: 10.1016/j.cub.2023.05.002.

Authors

Lloyd Cool¹, Samuel Hanon¹, Kevin J Verstrepen²

Affiliations

¹ VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium.
² VIB Laboratory for Systems Biology, VIB-KU Leuven Center for Microbiology, Leuven, 3001, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Leuven, 3001, Belgium. Electronic address: kevin.verstrepen@kuleuven.be.

PMID: 37279666
DOI: 10.1016/j.cub.2023.05.002

Abstract

A new study finds that Schizosaccharomyces japonicus, a eukaryote that lost the ability to respire, modified its central carbon metabolism to maintain efficient ATP production, cofactor regeneration, and amino-acid production. This remarkable metabolic flexibility opens new avenues towards applications.

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MeSH terms

Eukaryota*
Respiration*