Unilateral cerebral arterial tortuosity: Associated with aneurysm occurrence, but potentially inversely associated with aneurysm rupture

Ran Li; Pengyu Zhou; Evan Kao; Chengcheng Zhu; Mahmud Mossa-Basha; Yuting Wang

doi:10.1016/j.ejrad.2023.110941

Unilateral cerebral arterial tortuosity: Associated with aneurysm occurrence, but potentially inversely associated with aneurysm rupture

Eur J Radiol. 2023 Aug:165:110941. doi: 10.1016/j.ejrad.2023.110941. Epub 2023 Jun 20.

Authors

Ran Li¹, Pengyu Zhou¹, Evan Kao², Chengcheng Zhu³, Mahmud Mossa-Basha³, Yuting Wang⁴

Affiliations

¹ Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
³ Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA.
⁴ Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: wangyuting_330@163.com.

PMID: 37354772
DOI: 10.1016/j.ejrad.2023.110941

Abstract

Purpose: To investigate the association of tortuosity of the main cerebral arteries with intracranial aneurysm (IA) occurrence and rupture. To investigate the relationship between arterial tortuosity and aneurysm morphology as well as conventional risk factors of vascular diseases.

Methods: Three subject groups were analyzed in this study: Patients with ruptured IAs, patients with unruptured IAs, and healthy subjects. The groups were matched by sex and age using tendency score matching. Their intracranial magnetic resonance angiography (MRA) images were collected retrospectively. The intracranial arterial structures were segmented from the MRA images. Arterial tortuosity was measured and statistically compared between the different subject groups and different vessels. Correlation analysis was conducted between arterial tortuosity and clinical risk factors as well as aneurysm morphology.

Results: 120 patients were included in the study (average age: 67.5 years; 60% female), 40 for each group after matching. The tortuosity of the aneurysm-bearing artery was significantly greater than that of the contralateral artery in both the ruptured and unruptured IA groups (p < 0.001). There was no significant association between clinical risk factors (history of hypertension, hyperlipidemia, diabetes, smoking, and alcohol use) and arterial tortuosity. There were significant negative correlations between aneurysm-bearing artery tortuosity and aneurysm morphological features such as maximal diameter (p = 0.0011), neck diameter (p < 0.0001), maximum height (p = 0.0024), and size ratio (p = 0.0269).

Conclusion: The occurrence of cerebral aneurysms correlates to increased unilateral arterial tortuosity, but the risk of aneurysm enlargement/rupturing decreases with greater arterial tortuosity. Abnormal tortuosity may be congenital as tortuosity has no clear connection with acquired common risk factors of vascular diseases.

Keywords: Aneurysm; Arterial tortuosity; Magnetic resonance angiography (MRA).

MeSH terms

Aged
Aneurysm, Ruptured* / diagnostic imaging
Aneurysm, Ruptured* / pathology
Cerebral Angiography / methods
Cerebral Arteries / diagnostic imaging
Female
Humans
Intracranial Aneurysm* / complications
Intracranial Aneurysm* / diagnostic imaging
Intracranial Aneurysm* / epidemiology
Male
Retrospective Studies
Risk Factors

Supplementary concepts

Arterial Tortuosity Syndrome