Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha

Sujeet Kumar; Sunil Swick Rout; Sarita Kar; Himadri Bhusan Bal; Jyotirmayee Turuk; Dasarathi Das; Prasanta Kumar Hota; Sanghamitra Pati; Sidhartha Giri

doi:10.1016/j.ijmmb.2023.100373

Pattern of InhA and KatG mutations in isoniazid mono resistant Mycobacterium tuberculosis isolates from Odisha

Indian J Med Microbiol. 2023 Jul-Aug:44:100373. doi: 10.1016/j.ijmmb.2023.100373. Epub 2023 May 11.

Authors

Sujeet Kumar¹, Sunil Swick Rout¹, Sarita Kar¹, Himadri Bhusan Bal¹, Jyotirmayee Turuk², Dasarathi Das², Prasanta Kumar Hota³, Sanghamitra Pati², Sidhartha Giri⁴

Affiliations

¹ National Reference Laboratory for TB, ICMR-Regional Medical Research Centre, Bhubaneswar, 751023, Odisha, India.
² ICMR-Regional Medical Research Centre, Bhubaneswar, 751023, Odisha, India.
³ Government of Odisha, India.
⁴ ICMR-Regional Medical Research Centre, Bhubaneswar, 751023, Odisha, India. Electronic address: sidhartha.g@icmr.gov.in.

PMID: 37356845
DOI: 10.1016/j.ijmmb.2023.100373

Abstract

We conducted a retrospective analysis of the line probe assay (LPA) data during January to December 2019, from 8 districts of Odisha. The prevalence of Hr-TB (isoniazid resistance only) was 1.53% (50/3272) with a range of 0-3.4% in the 8 districts. Of the 50 Hr-TB strains, katG mutation and inhA mutations were seen in 74% (37/50) and 26% (13/50) strains respectively. S315T1 and C15T were common mutations in katG and inhA respectively. Since these mutations are closely related to high- or low degree resistance to INH, it has therapeutic implications.

Keywords: Isoniazid; Mutation; Mycobacterium tuberculosis; Rifampicin.

MeSH terms

Bacterial Proteins* / genetics
Drug Resistance, Bacterial*
India
Isoniazid* / pharmacology
Mutation
Mycobacterium tuberculosis* / drug effects
Mycobacterium tuberculosis* / genetics

Substances

InhA protein, Mycobacterium
katG protein, Mycobacterium tuberculosis
Isoniazid
Bacterial Proteins