Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics

G Vinaya Chandu Vidyasagar; P V Janardhan Reddy; Somesh Kumar; Sunil Kumar Polipalli; Ram Mohan Jaiswal; T C Venkateswarulu; P B Kavi Kishor; Prashanth Suravajhala; Rathnagiri Polavarapu

doi:10.1007/978-3-031-28012-2_16

Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics

Adv Exp Med Biol. 2023:1412:285-310. doi: 10.1007/978-3-031-28012-2_16.

Authors

Affiliations

¹ Genomix CARL Pvt. Ltd., Pulivendula, AP, India.
² Department of Biotechnology, Vignan's Foundation for Science, Technology & Research, Guntur, AP, India.
³ Genome Sequencing Laboratory, Lok Nayak Hospital, Jawaharlal Nehru Marg, New Delhi, India.
⁴ Bioclues.org, Hyderabad, Telangana, India.
⁵ Blood Centre and Transplantation Immunology Lab, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India.
⁶ Department of Genetics, Osmania University, Hyderabad, India.
⁷ Bioclues.org, Hyderabad, Telangana, India. prash@am.amrita.edu.
⁸ Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Clappana, Kerala, India. prash@am.amrita.edu.
⁹ Genomix CARL Pvt. Ltd., Pulivendula, AP, India. giri@genomixbiotech.com.

^# Contributed equally.

PMID: 37378774
DOI: 10.1007/978-3-031-28012-2_16

Abstract

Point-of-care SARS-CoV-2 rapid antigen tests have proven to be useful over the years and have become more apparent to the public eye during COVID-19 pandemic due to their ease of use, rapid processing and result times, and low cost. Here, we have assessed the effectiveness and accuracy of rapid antigen tests in comparison to the standard real-time polymerase chain reaction analyses of the same samples.

Keywords: COVID-19; Diagnosis; Polymerase chain reaction; Rapid antigen test; SARS-CoV-2; Sensitivity; Specificity.

MeSH terms

COVID-19* / diagnosis
Humans
Immunologic Tests
Pandemics
Precision Medicine*
SARS-CoV-2 / genetics
Sensitivity and Specificity