Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration

B H Scammell; C Tchio; Y Song; T Nishiyama; T L Louie; H S Dashti; M Nakatochi; P C Zee; I Daghlas; Y Momozawa; J Cai; H M Ollila; S Redline; K Wakai; T Sofer; S Suzuki; J M Lane; R Saxena

doi:10.1093/hmg/ddad101

Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration

Hum Mol Genet. 2023 Sep 5;32(18):2797-2807. doi: 10.1093/hmg/ddad101.

Authors

B H Scammell^{1

2}, C Tchio^{1

2

3

4}, Y Song^{1

2}, T Nishiyama⁵, T L Louie⁶, H S Dashti^{1

2

3}, M Nakatochi⁷, P C Zee⁸, I Daghlas^{1

2}, Y Momozawa⁹, J Cai¹⁰, H M Ollila^{1

2

3

11}, S Redline^{12

13}, K Wakai¹⁴, T Sofer^{6

12

13}, S Suzuki⁵, J M Lane^{1

2

12

13}, R Saxena^{1

2

3}

Affiliations

¹ Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02215, USA.
² Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02141, USA.
³ Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
⁴ Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA.
⁵ Department of Public Health, Nagoya City University Graduate School of Medicine, Nagoya 467-8701, Japan.
⁶ Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.
⁷ Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya 467-8701, Japan.
⁸ Center for Circadian and Sleep Medicine, Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
⁹ Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
¹⁰ Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
¹¹ Institute for Molecular Medicine, HiLIFE, University of Helsinki, Helsinki 00014, Finland.
¹² Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
¹³ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
¹⁴ Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 467-8701, Japan.

PMID: 37384397
PMCID: PMC10656946 (available on 2024-06-29)
DOI: 10.1093/hmg/ddad101

Abstract

Both short (≤6 h per night) and long sleep duration (≥9 h per night) are associated with increased risk of chronic diseases. Despite evidence linking habitual sleep duration and risk of disease, the genetic determinants of sleep duration in the general population are poorly understood, especially outside of European (EUR) populations. Here, we report that a polygenic score of 78 European ancestry sleep duration single-nucleotide polymorphisms (SNPs) is associated with sleep duration in an African (n = 7288; P = 0.003), an East Asian (n = 13 618; P = 6 × 10-4) and a South Asian (n = 7485; P = 0.025) genetic ancestry cohort, but not in a Hispanic/Latino cohort (n = 8726; P = 0.71). Furthermore, in a pan-ancestry (N = 483 235) meta-analysis of genome-wide association studies (GWAS) for habitual sleep duration, 73 loci are associated with genome-wide statistical significance. Follow-up of five loci (near HACD2, COG5, PRR12, SH3RF1 and KCNQ5) identified expression-quantitative trait loci for PRR12 and COG5 in brain tissues and pleiotropic associations with cardiovascular and neuropsychiatric traits. Overall, our results suggest that the genetic basis of sleep duration is at least partially shared across diverse ancestry groups.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study* / methods
Humans
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Self Report
Sleep / genetics
Sleep Duration*

Abstract

Publication types

MeSH terms

Grants and funding