Screening of attention and executive functions in pediatric patients at a tertiary epilepsy center

Lisa E Hauger; Morten I Lossius; Kari M Aaberg; Christoph Helmstaedter; Johanne Lossius; Annette H Skogan

doi:10.1016/j.ejpn.2023.06.006

Screening of attention and executive functions in pediatric patients at a tertiary epilepsy center

Eur J Paediatr Neurol. 2023 Sep:46:35-41. doi: 10.1016/j.ejpn.2023.06.006. Epub 2023 Jun 25.

Authors

Lisa E Hauger¹, Morten I Lossius², Kari M Aaberg³, Christoph Helmstaedter⁴, Johanne Lossius⁵, Annette H Skogan⁶

Affiliations

¹ National Centre for Epilepsy, Division for Clinical Neuroscience, Oslo University Hospital, Postbox 4959, Nydalen, Norway. Electronic address: haulis@ous-hf.no.
² National Centre for Epilepsy, Division for Clinical Neuroscience, Oslo University Hospital, Postbox 4959, Nydalen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: mortenl@ous-hf.no.
³ National Centre for Epilepsy, Division for Clinical Neuroscience, Oslo University Hospital, Postbox 4959, Nydalen, Norway. Electronic address: kaaabe@ous-hf.no.
⁴ Department of Epileptology, University Hospital Bonn, Building 83, Venusberg - Campus 1, 53127, Bonn, Germany. Electronic address: christoph.helmstaedter@ukbonn.de.
⁵ National Centre for Epilepsy, Division for Clinical Neuroscience, Oslo University Hospital, Postbox 4959, Nydalen, Norway. Electronic address: johanne.lossius@gmail.com.
⁶ National Centre for Epilepsy, Division for Clinical Neuroscience, Oslo University Hospital, Postbox 4959, Nydalen, Norway. Electronic address: uxskaw@ous-hf.no.

PMID: 37418997
DOI: 10.1016/j.ejpn.2023.06.006

Abstract

Objective: Executive dysfunction is prevalent in children with epilepsy, and associated with poor psychosocial outcome. Sensitive and time effective tools are needed, which capture executive dysfunction across a wide range of impairment. The present study evaluates the applicability of EpiTrack Junior® (EpiTrackJr) as a screening tool at a tertiary epilepsy center, and explore how EpiTrackJr in combination with a subjective measure of everyday attention and executive functions (EFs) may provide clinically important information.

Methods: Retrospective study including 235 pediatric patients admitted to the Norwegian National Centre for Epilepsy. EpiTrackJr and Behavioral Rating Inventory of Executive Functioning (BRIEF) were used to assess attention and EFs.

Results: 27,7% obtained a score categorized as "average/unimpaired", 23% as "mildly impaired", and 47.7% as "significantly impaired" on EpiTrackJr. The distribution of age-corrected EpiTrackJr scores was satisfactory. Performance was related to numbers of anti-seizure medication (ASM load), comorbidity and IQ. We found a significant, but weak correlation between EpiTrackJr performance and the BRIEF Metacognitive Index (r = -0.236, n = 108, p=.014), but no significant correlation with the Behavioral Regulation Index (r = -0.178, n = 108, p=.065).

Significance: Our results indicate that EpiTrackJr is applicable as a screening tool for attention and EFs in pediatric patients at a tertiary epilepsy center. Impaired test performance was associated with greater ASM load, comorbidity and lower IQ. Performance based measures and behavior ratings likely capture different aspects of EFs. In combination, the two provide important and nonredundant information about the child's EFs in different settings.

Keywords: Attention; BRIEF; Cognitive screening; EpiTrack Junior; Executive function; Neuropsychology.