Type 2 diabetes (T2DM) is a complex metabolic disorder manifested by hyperglycemia, insulin resistance, and deteriorating beta-cell function. A way to prevent progression of the disease might be to enhance beta-cell function and insulin secretion. However, most previous studies examined beta-cell function while patients were using glycemia-lowering agents without an adequate period off medications (washout). In the present review we focus on studies with a washout period. We performed a literature search (2010 to June 2021) using beta-cell function and enhancement. The evidence shows that beta-cell function can be enhanced. Bariatric surgery and very low calorie diets show improvement in beta-cell function in many individuals. In addition, use of glucagon-like peptide-1 receptor agonists for prolonged periods (3 years or more) can also lead to improvement of beta-cell function. Further research is needed to understand the mechanisms leading to improved beta-cell function and identify agents that could enhance beta-cell function in patients with T2DM.
2型糖尿病(T2DM)是一种复杂的代谢紊乱，表现为高血糖、胰岛素抵抗和β细胞功能逐渐恶化。预防该疾病进展的一种方法是增强β细胞功能和胰岛素分泌。然而，此前大多数研究在患者使用降糖药物且没有足够的时间停药(洗脱期)的情况下检查了β细胞功能。在本文中，我们重点讨论了有洗脱期的研究。我们使用了β细胞功能和增强作为关键词进行了文献检索(2010年至2021年6月)。现有证据表明，β细胞功能可以增强。减重手术和极低热量饮食可改善许多个体的β细胞功能。此外，使用GLP-1受体激动剂进行长期治疗(3年或更长时间)也可以改善β细胞功能。需要进一步的研究来了解导致改善β细胞功能的机制，并确定可以增强T2DM患者β细胞功能的药物。.
Keywords: beta-cell mass; beta-cell replication; beta-cell survival; disposition index; insulin resistance; β细胞复制; β细胞存活; β细胞数量; 处置指数; 胰岛素抵抗.
© 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.