Macropinocytosis: Blowing bubbles

Curr Biol. 2023 Aug 7;33(15):R812-R814. doi: 10.1016/j.cub.2023.06.053.

Abstract

Macropinocytosis is a form of endocytosis in which cells engulf relatively large quantities of extracellular fluid through cup-shaped invaginations of the plasma membrane. New work shows that macropinosome closure occurs without a localized constriction of actin filaments, indicating that membrane tension drives cup closure.

Publication types

  • Comment

MeSH terms

  • Actin Cytoskeleton
  • Cell Membrane
  • Endocytosis*
  • Endosomes
  • Pinocytosis*