Multimodality imaging of hypertrophic cardiomyopathy

Tiffany Dong; Yvonne Gilliland; Christopher M Kramer; Abraham Theodore; Milind Desai

doi:10.1016/j.pcad.2023.08.004

Multimodality imaging of hypertrophic cardiomyopathy

Prog Cardiovasc Dis. 2023 Sep-Oct:80:14-24. doi: 10.1016/j.pcad.2023.08.004. Epub 2023 Aug 14.

Authors

Tiffany Dong¹, Yvonne Gilliland², Christopher M Kramer³, Abraham Theodore⁴, Milind Desai⁵

Affiliations

¹ Section of Cardiovascular Imaging, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
² Department of Cardiology, Ochsner Medical Center, New Orleans, LA, USA; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA, USA.
³ Cardiovascular Division, Department of Medicine, University of Virginia Health, Charlottesville, VA, USA.
⁴ Division of Cardiology, University of California San Francisco, San Francisco, CA, USA.
⁵ Section of Cardiovascular Imaging, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: desaim2@ccf.org.

PMID: 37586654
DOI: 10.1016/j.pcad.2023.08.004

Abstract

The diagnosis and management of hypertrophic cardiomyopathy (HCM) requires multimodality imaging. Transthoracic echocardiogram (TTE) remains the first-line imaging modality to diagnose HCM identifying morphology and obstruction, which includes left ventricular outflow obstruction, midcavitary obstruction and systolic anterior motion. Cardiac magnetic resonance imaging (CMR) can adjudicate equivocal cases, rule out alternative diagnoses and evaluate for risk factors of sudden cardiac death. Imaging with TTE or transesophageal echocardiogram can also guide alcohol septal ablation or surgical myectomy respectively. Furthermore, TTE can guide medical management of these patients by following peak gradients. Thus, multimodality imaging in HCM is crucial throughout the course of these patients' care.

Keywords: Alcohol septal ablation; Cardiac magnetic resonance imaging; Hypertrophic cardiomyopathy; Mavacamten; Myectomy; Septal reduction; Sudden cardiac death; Transesophageal echocardiogram; Transthoracic echocardiogram.

Publication types

Review

MeSH terms

Cardiomyopathy, Hypertrophic* / diagnostic imaging
Cardiomyopathy, Hypertrophic* / therapy
Echocardiography
Echocardiography, Transesophageal / adverse effects
Humans
Multimodal Imaging
Ventricular Outflow Obstruction* / etiology
Ventricular Outflow Obstruction* / surgery

Grants and funding

U01 HL117006/HL/NHLBI NIH HHS/United States