IL-22: Immunity's bittersweet symphony

J Exp Med. 2023 Nov 6;220(11):e20231210. doi: 10.1084/jem.20231210. Epub 2023 Sep 11.

Abstract

Epithelial cells play a crucial role in barrier defense. Here, Moniruzzaman et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230106) discovered that interleukin-22 (IL-22) represses MHC class II expression by epithelial cells with an opposite impact on chronic inflammatory disease and viral infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Epithelial Cells*
  • Genes, MHC Class II
  • Interleukin-22
  • Interleukins*

Substances

  • Interleukins