Background free in vivo29Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

Seung-Hyun Yang; Jiwon Kim; Tae Geol Lee; Mirae Park; Hye Young Son; Chan Gyu Joo; Jeong Hyun Shim; Youngbok Lee; Yong-Min Huh

doi:10.1039/d3an01395b

Background free in vivo²⁹Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

Analyst. 2023 Oct 23;148(21):5355-5360. doi: 10.1039/d3an01395b.

Authors

Seung-Hyun Yang^{1

2}, Jiwon Kim³, Tae Geol Lee⁴, Mirae Park¹, Hye Young Son^{1

2}, Chan Gyu Joo⁵, Jeong Hyun Shim⁴, Youngbok Lee^{3

6}, Yong-Min Huh^{1

2

7}

Affiliations

¹ Department of Radiology, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea. YMHUH@yuhs.ac.
² YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
³ Department of Bionano Technology, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, 15588, Republic of Korea. yblee@hanyang.ac.kr.
⁴ Korea Research Institute of Standards and Science, Daejeon, 34113, Republic of Korea. jhshim@kriss.re.kr.
⁵ Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.
⁶ Department of Applied Chemistry, Hanyang University, Ansan, 15588, Republic of Korea.
⁷ Department of Biochemistry & Molecular Biology, College of Medicine, Yonsei University, Seoul, 03722, Republic of Korea.

PMID: 37750298
DOI: 10.1039/d3an01395b

Abstract

This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolution in vivo²⁹Si MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si MR images using the lowest reported dose after subcutaneous and intraperitoneal administration opens new avenues for future ²⁹Si MR studies.