Viral Suppression Trajectories Destabilized After Coronavirus Disease 2019 Among US People With Human Immunodeficiency Virus: An Interrupted Time Series Analysis

Matthew A Spinelli; Katerina A Christopoulos; Carlos V Moreira; Jennifer P Jain; Nadra Lisha; David V Glidden; Greer A Burkholder; Heidi M Crane; Adrienne E Shapiro; Jeffrey M Jacobson; Edward R Cachay; Kenneth H Mayer; Sonia Napravnik; Richard D Moore; Monica Gandhi; Mallory O Johnson

doi:10.1093/cid/ciad657

Viral Suppression Trajectories Destabilized After Coronavirus Disease 2019 Among US People With Human Immunodeficiency Virus: An Interrupted Time Series Analysis

Clin Infect Dis. 2024 Apr 10;78(4):991-994. doi: 10.1093/cid/ciad657.

Authors

Matthew A Spinelli¹, Katerina A Christopoulos¹, Carlos V Moreira¹, Jennifer P Jain², Nadra Lisha³, David V Glidden³, Greer A Burkholder⁴, Heidi M Crane⁵, Adrienne E Shapiro^{5

6}, Jeffrey M Jacobson⁷, Edward R Cachay⁸, Kenneth H Mayer⁹, Sonia Napravnik¹⁰, Richard D Moore¹¹, Monica Gandhi¹, Mallory O Johnson²

Affiliations

¹ Division of HIV, ID, and Global Medicine, University of California, SanFrancisco, California, USA.
² Division of Prevention Science, University of California, SanFrancisco, California, USA.
³ Department of Epidemiology and Biostatistics, University of California, SanFrancisco, California, USA.
⁴ Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham,Alabama, USA.
⁵ Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
⁶ Department of Global Health, University of Washington, Seattle, Washington, USA.
⁷ Divsion of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
⁸ Division of Infectious Diseases, University of California, San Diego, California, USA.
⁹ Department of Medicine, Harvard University and the Fenway Institute/Fenway Health, Boston, Massachusetts, USA.
¹⁰ Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
¹¹ Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.

PMID: 37963086
PMCID: PMC11006098 (available on 2024-11-14)
DOI: 10.1093/cid/ciad657

Abstract

We examined changes in the proportion of people with human immunodeficiency virus (PWH) with virologic suppression (VS) in a multisite US cohort before and since the coronavirus disease 2019 (COVID-19) pandemic. Overall, prior gains in VS slowed during COVID-19, with disproportionate impacts on Black PWH and PWH who inject drugs.

Keywords: HIV; Racial disparities; people who inject drugs; post-COVID-19; virologic suppression.

MeSH terms

COVID-19*
HIV
HIV Infections* / complications
HIV Infections* / epidemiology
Humans
Interrupted Time Series Analysis

Abstract

MeSH terms

Grants and funding