The significance of mitochondrial haplogroups in preeclampsia risk

Kristina Wendelboe Olsen; Paula L Hedley; Christian M Hagen; Line Rode; Sophie Placing; Karen R Wøjdemann; Anne-Cathrine Shalmi; Karin Sundberg; Anne Nørremølle; Ann Tabor; Joanna L Elson; Michael Christiansen

doi:10.1016/j.preghy.2023.11.001

The significance of mitochondrial haplogroups in preeclampsia risk

Pregnancy Hypertens. 2023 Dec:34:146-151. doi: 10.1016/j.preghy.2023.11.001. Epub 2023 Nov 16.

Authors

Affiliations

¹ Fertility Department, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.
² Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark; Brazen Bio, Los Angeles, CA, USA.
³ Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
⁴ Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, 2600 Glostrup, Denmark.
⁵ Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark.
⁶ Department of Gynecology and Obstetrics, Bornholm Hospital, 3700 Rønne, Bornholm, Denmark.
⁷ Department of Obstetrics, Hillerød Sygehus, 3400 Hillerød, Denmark.
⁸ Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.
⁹ Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
¹⁰ Center of Fetal Medicine, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
¹¹ Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark; Biosciences Institute Newcastle University, Newcastle, UK; The Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa. Electronic address: j.l.elson@ncl.ac.uk.

PMID: 37979242
DOI: 10.1016/j.preghy.2023.11.001

Abstract

Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.

Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.

Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.

Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

Keywords: Mitochondrial DNA; Mitochondrial haplogroups; Preeclampsia; Pregnancy.

MeSH terms

DNA, Mitochondrial / genetics
Female
Haplotypes
Humans
Mitochondria / genetics
Pre-Eclampsia* / genetics
Retrospective Studies

Substances

DNA, Mitochondrial