The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients

J Denis; A Garnier; D Claverie; F De Laval; S Attoumani; B Tenebray; G A Durand; B Coutard; I Leparc-Goffart; J N Tournier; S Briolant; C Badaut

doi:10.1016/j.heliyon.2023.e21945

The Wood equation allows consistent fitting of individual antibody-response profiles of Zika virus or SARS-CoV-2 infected patients

Heliyon. 2023 Nov 7;9(11):e21945. doi: 10.1016/j.heliyon.2023.e21945. eCollection 2023 Nov.

Authors

J Denis^{1

2}, A Garnier¹, D Claverie³, F De Laval^{4

5}, S Attoumani⁶, B Tenebray^{2

6}, G A Durand^{2

6}, B Coutard⁶, I Leparc-Goffart^{2

6}, J N Tournier^{1

7

8}, S Briolant^{9

10}, C Badaut^{6

11}

Affiliations

¹ Unité Interaction Hôte - Pathogene, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
² Centre National de Référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, France.
³ Unité de Neurophysiologie du Stress, Institut de Recherche Biomédicale des Armées, 1 place du Général Valérie André BP73, Brétigny-sur-Orge Cedex, France.
⁴ Service de Santé des Armées, Centre d'Epidémiologie et de Santé Public des Armées, Marseille, France.
⁵ Aix Marseille Université, INSERM, SESSTIM, Science Economique & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.
⁶ Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.
⁷ Institut Pasteur, Innovative Vaccine Laboratory, Paris, France.
⁸ Ecole du Val-de-Grâce, Paris, France.
⁹ Unité de Parasitologie et Entomologie, Département de Microbiologie et des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France.
¹⁰ Aix Marseille Université, IRD, AP-HM, SSA, UMR vecteurs - Infections Tropicales et Méditerranéennes (VITROME), IHU - Méditerranée Infection, Marseille, France.
¹¹ Unité de virologie, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.

Abstract

Antibody kinetic curves obtained during a viral infection are often fitted using aggregated patient data, hiding the heterogeneity of individual humoral immune responses. Individual antibody responses can be modeled using the Wood equation and grouped according to their profile. Such modeling takes into account several important kinetic parameters, such as the day when antibody detection becomes positive [daypos], the day of the maximal response [daymax], the maximum antibody level [levelmax], and the day when antibody detection becomes negative [dayneg]. Potential associations between these profiles and studied factors can then be tested.

Keywords: Curve fit; Humoral immune response; Kinetic; SARS-CoV-2; Wood equation; Zika virus.