Role of immunometabolism during congenital cytomegalovirus infection

Kevin J Zwezdaryk; Amitinder Kaur

doi:10.1097/IN9.0000000000000034

Role of immunometabolism during congenital cytomegalovirus infection

Immunometabolism (Cobham). 2023 Nov 28;5(4):e00034. doi: 10.1097/IN9.0000000000000034. eCollection 2023 Oct.

Authors

Kevin J Zwezdaryk^{1

2

3}, Amitinder Kaur^{1

4}

Affiliations

¹ Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
² Tulane Center for Aging, Tulane University School of Medicine, New Orleans, LA, USA.
³ Tulane Brain Institute, Tulane University School of Medicine, New Orleans, LA, USA.
⁴ Division of Immunology, Tulane National Primate Research Center, Covington, LA, USA.

Abstract

Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter metabolism in uninfected neighboring cells. In this mini review, we discuss how CMV infection may impact immune function through metabolic pathways. We discuss how immune cells differ between maternal and decidual compartments and how altered immunometabolism may contribute to congenital infections.

Keywords: congenital cytomegalovirus; immunometabolism; placenta.

Grants and funding

P51 OD011104/OD/NIH HHS/United States