An unusual cause of progressive dyspnoea, pulmonary nodules and pleural effusions

Sudharsan Venkatesan; Bharti Ramnani; Sonja Klebe; Lin Mo

doi:10.1002/rcr2.1261

An unusual cause of progressive dyspnoea, pulmonary nodules and pleural effusions

Respirol Case Rep. 2023 Nov 30;12(1):e01261. doi: 10.1002/rcr2.1261. eCollection 2024 Jan.

Authors

Sudharsan Venkatesan^{1

2}, Bharti Ramnani³, Sonja Klebe^{2

4}, Lin Mo^{1

2}

Affiliations

¹ Division of Medicine Royal Darwin Hospital Darwin Northern Territory Australia.
² College of Medicine and Public Health Flinders University Darwin Northern Territory Australia.
³ Department of Anatomical Pathology Royal Darwin Hospital Darwin Northern Territory Australia.
⁴ Department of Anatomical Pathology Flinders Medical Centre Adelaide South Australia Australia.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is part of the ANCA-associated vasculitides, although ANCA-negative presentations are not infrequent. Asthma, allergic rhinitis and peripheral eosinophilia are classic associations although pleural effusions are an uncommon manifestation of EGPA. We describe a 35-year old Caucasian adult with asthma who presented with progressive dyspnoea, cough, peripheral eosinophilia and imaging that showed pulmonary nodules with pleural effusions. Biopsy with histopathological review confirmed the diagnosis of EGPA with steroid therapy resulting in significant resolution of symptoms and imaging findings.

Keywords: ANCA‐negative EGPA; nodules; pleural effusions.

Publication types

Case Reports