The feasibility of a multidimensional intervention in lymphoma survivors with chronic fatigue

Skh Bøhn; L M Oldervoll; K V Reinertsen; M Seland; A Fosså; C Kiserud; T Skaali; T S Nilsen; R Blomhoff; H B Henriksen; H C Lie; T Berge; E Fjerstad; T Wisløff; M Slott; I Zajmovic; L Thorsen

doi:10.1007/s00520-023-08204-5

The feasibility of a multidimensional intervention in lymphoma survivors with chronic fatigue

Support Care Cancer. 2023 Dec 14;32(1):22. doi: 10.1007/s00520-023-08204-5.

Authors

Skh Bøhn¹, L M Oldervoll^{2

3}, K V Reinertsen⁴, M Seland⁵, A Fosså⁴, C Kiserud⁴, T Skaali⁵, T S Nilsen⁶, R Blomhoff^{7

8}, H B Henriksen⁷, H C Lie⁹, T Berge¹⁰, E Fjerstad¹⁰, T Wisløff¹¹, M Slott⁵, I Zajmovic⁵, L Thorsen^{4

8}

Affiliations

¹ National Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway. synn@ous-hf.no.
² Centre for Crisis Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.
³ Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
⁴ National Advisory Unit for Late Effects After Cancer Treatment, Department of Oncology, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
⁵ Department of Clinical Service, The Cancer Rehabilitation Center, Aker, Oslo University Hospital, Oslo, Norway.
⁶ Institute of Physical Performance, Norwegian School of Sports Sciences, Oslo, Norway.
⁷ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁸ Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway.
⁹ Department of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
¹⁰ Diakonhjemmet Hospital, Oslo, Norway.
¹¹ Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.

Abstract

Purpose: Chronic fatigue (CF) affects 25-30% of lymphoma survivors, but interventions designed to reduce fatigue are lacking. The main aim of this study was to test the feasibility of a multidimensional intervention study in lymphoma survivors with CF. Secondary aims were to describe individual changes in fatigue, quality of life (QoL) and physical performance from pre (T0) to post (T1) intervention.

Methods: This feasibility study was as a one-armed intervention study performed in 2021. Hodgkin or aggressive non-Hodgkin lymphoma survivors received mailed study information and Chalder Fatigue Questionnaire and were asked to respond if they suffered from fatigue. The 12-week intervention included patient education, physical exercise, a cognitive behavioural therapy (CBT)-based group program and nutritional counselling. Feasibility data included patient recruitment, completion of assessments, adherence to the intervention and patient-reported experience measures. Participants responded to questionnaires and underwent physical tests at T0 and T1.

Results: Seven lymphoma survivors with CF were included. Of all assessments, 91% and 83% were completed at T0 and T1, respectively. Adherence to the interventional components varied from 69% to 91%. At T1, all participants rated exercise as useful, of whom five rated the CBT-based program and five rated individual nutritional counselling as useful. Five participants reported improved fatigue, QoL and physical performance.

Conclusion: Lymphoma survivors with CF participating in a multidimensional intervention designed to reduce the level of fatigue showed high assessment completion rate and intervention adherence rate. Most of the participants evaluated the program as useful and improved their level of fatigue, QoL and physical performance after the intervention.

Trial registration: ClinicalTrials.gov, identifier: NCT04931407. Registered 16. April 2021-Retrospectively registered. https://www.

Clinicaltrials: gov/ct2/show/NCT04931407.

Keywords: Chronic fatigue; Cognitive behavioural therapy; Exercise; Lymphoma survivors; Nutrition; Patient education.

MeSH terms

Fatigue Syndrome, Chronic*
Feasibility Studies
Humans
Lymphoma, Non-Hodgkin*
Quality of Life
Survivors

Associated data

ClinicalTrials.gov/NCT04931407