Clinical and patient-reported outcomes of periodontal phenotype modification therapy using injectable platelet rich fibrin with microneedling and free gingival grafts: A prospective clinical trial

Sathya Valli Veluri; Sruthima Nvs Gottumukkala; Gautami S Penmetsa; Ksv Ramesh; Mohan Kumar P; Vivek Bypalli; Sravanthi Vundavalli; Dinesh Gera

doi:10.1016/j.jormas.2023.101744

Clinical and patient-reported outcomes of periodontal phenotype modification therapy using injectable platelet rich fibrin with microneedling and free gingival grafts: A prospective clinical trial

J Stomatol Oral Maxillofac Surg. 2023 Dec 19;125(4):101744. doi: 10.1016/j.jormas.2023.101744. Online ahead of print.

Authors

Sathya Valli Veluri¹, Sruthima Nvs Gottumukkala², Gautami S Penmetsa¹, Ksv Ramesh¹, Mohan Kumar P¹, Vivek Bypalli¹, Sravanthi Vundavalli¹, Dinesh Gera¹

Affiliations

¹ Department of Periodontics and Implantology, Vishnu Dental College, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh 534202, India.
² Department of Periodontics and Implantology, Vishnu Dental College, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh 534202, India. Electronic address: sruthima@gmail.com.

PMID: 38128879
DOI: 10.1016/j.jormas.2023.101744

Abstract

Background: To evaluate the clinical non-inferiority of injectable platelet-rich fibrin and micro-needling (iPRF+MN) with free gingival grafting (FGG) in periodontal phenotype modification therapy.

Methodology: Twenty participants with a gingival thickness (GT)<0.8 mm in the mandibular anterior region were included. The participants were randomly allocated into i-PRF+MN and FGG groups. i-PRF injection was done, and MN was done with the help of a lancet in the i-PRF+MN group. The clinical parameters, i.e., GT and Keratinized tissue width (KTW), were evaluated at baseline, 3 and 6 months post-operatively. Patient-reported outcomes (PROs), i.e., discomfort and esthetic satisfaction, were assessed using the visual analogue score(VAS) at one week and 3 months of re-evaluation, respectively.

Results: Both groups showed a significant increase in GT and KTW with no intergroup variation (P-0.32, 0.48respectively) at the end of 6 months. However, the i-PRF+ MN group showed better PROs, i.e., less discomfort(1.11±0.60) and better esthetic satisfaction(8.77±0.44).

Conclusion: The non-invasive treatment of i-PRF+MN may lead to non-inferior clinical outcomes after 6 months with better PROs compared to more invasive FGG protocols in phenotype modification therapy.

Keywords: Free gingival graft; Gingival augmentation; Injectable platelet-rich fibrin; Keratinized gingiva; Periodontal phenotype.