Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Cell Commun Signal. 2024 Jan 15;22(1):40. doi: 10.1186/s12964-023-01458-w.

Abstract

Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59. Emerging evidences have shown that pyroptosis contributes to many pulmonary diseases, especially lung cancer, and pneumonia. The exact roles of pyroptosis and gasdermin family proteins are tremendously intricate. Besides, there are evidences that pyroptosis contributes to these respiratory diseases. However, it often plays a dual role in these diseases which is a cause for concern and makes it difficult for clinical translation. This review will focus on the multifaceted roles of pyroptosis in respiratory diseases.

Keywords: Caspase; Gasdermin; Lung cancer; Pneumonia; Pyroptosis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor
  • Cell Death
  • Gasdermins
  • Humans
  • Lung Neoplasms*
  • Neoplasm Proteins / metabolism
  • Pyroptosis*

Substances

  • Gasdermins
  • Neoplasm Proteins
  • GSDMC protein, human
  • Biomarkers, Tumor
  • GSDMA protein, human