A Postoperative Nausea and Vomiting Update: Current information on New Drugs, Old Drugs, Rescue/Treatment, Combination Therapies and Nontraditional Modalities

Tricia A Meyer; Larry R Hutson Jr; Phillip M Morris; Russell K McAllister

doi:10.1016/j.aan.2023.05.002

A Postoperative Nausea and Vomiting Update: Current information on New Drugs, Old Drugs, Rescue/Treatment, Combination Therapies and Nontraditional Modalities

Adv Anesth. 2023 Dec;41(1):17-38. doi: 10.1016/j.aan.2023.05.002. Epub 2023 Jul 11.

Authors

Tricia A Meyer¹, Larry R Hutson Jr², Phillip M Morris³, Russell K McAllister⁴

Affiliations

¹ Texas A&M University-School of Medicine, Temple, TX, USA. Electronic address: triciameyer@tamu.edu.
² Texas A&M University-School of Medicine, Temple, TX, USA; Baylor College of Medicine - Temple, TX, USA; Department of Anesthesiology, Baylor Scott & White Medical Center-Temple, 2401 South 31st Street, Temple, TX 76508, USA.
³ Texas A&M University-School of Medicine, Temple, TX, USA; Department of Anesthesiology, Baylor Scott & White Medical Center-Temple, 2401 South 31st Street, Temple, TX 76508, USA.
⁴ Texas A&M University-School of Medicine, Temple, TX, USA; Baylor College of Medicine - Temple, TX, USA; Department of Anesthesiology, Baylor Scott & White Medical Center-Temple, 2401 South 31st Street, Temple, TX 76508, USA. Electronic address: Russell.McAllister@BSWHealth.org.

PMID: 38251617
DOI: 10.1016/j.aan.2023.05.002

Abstract

This article's objective is to present the latest evidence and information on the management of postoperative nausea and vomiting (PONV). PONV continues to affect 30% of the surgical population causing patient dissatisfaction, extending length of stay, and increasing overall costs. This review includes the introduction of 2 new intravenous formulations of antiemetics (amisulpride, aprepitant), updates on nontraditional therapies, suggestions for combination prophylaxis, emerging data on rescue treatment, and considerations for special populations and settings. Both of the new antiemetics provide promising options for pharmacologic interventions for PONV with favorable safety profiles.

Keywords: Amisulpride; Antiemetics; Aprepitant; Complementary therapies.

Publication types

Review

MeSH terms

Administration, Intravenous
Antiemetics* / therapeutic use
Aprepitant
Combined Modality Therapy
Humans
Postoperative Nausea and Vomiting* / drug therapy
Postoperative Nausea and Vomiting* / prevention & control

Substances

Antiemetics
Aprepitant