Dural involvement in central nervous system langerhans cells histiocytosis (LCH) on FDG PET/CT: Case report and review of CNS manifestations of LCH on PET/CT

Assim Saad Eddin; Parren McNeely; Mothana Saad Eldine; Lillian Lai; Ahmad Shariftabrizi

doi:10.1016/j.radcr.2023.12.044

Dural involvement in central nervous system langerhans cells histiocytosis (LCH) on FDG PET/CT: Case report and review of CNS manifestations of LCH on PET/CT

Radiol Case Rep. 2024 Jan 15;19(4):1391-1396. doi: 10.1016/j.radcr.2023.12.044. eCollection 2024 Apr.

Authors

Assim Saad Eddin¹, Parren McNeely¹, Mothana Saad Eldine¹, Lillian Lai¹, Ahmad Shariftabrizi¹

Affiliation

¹ University of Iowa Hospitals and Clinics; Department of Radiology; Iowa city, IA 52242, USA.

Abstract

We report a case of multisystem Langerhans cell histiocytosis in a pediatric patient with central nervous system involvement, highlighting F-18(FDG) uptake characteristics of dural sites of disease. We also highlight the advantages of functional data offered by FDG-PET as a useful follow-up tool to assess viability and, therefore, treatment response of previously known central nervous system lesions. The utility of recognizing characteristic patterns of FDG uptake in dural disease is also applicable in cases of diagnostic uncertainty, such as when evaluating isolated dural lesions or when distinguishing between Langerhans cell histiocytosis and similar appearing lesions such as meningiomas.

Keywords: CNS; Dural lesions; FDG avid; LCH; MRI; Pediatric case.

Published by Elsevier Inc. on behalf of University of Washington.

Publication types

Case Reports