Calcified Chondroid Mesenchymal Neoplasms

Erica Y Kao; Eleanor Y Chen

doi:10.1016/j.path.2023.06.006

Calcified Chondroid Mesenchymal Neoplasms

Surg Pathol Clin. 2024 Mar;17(1):77-82. doi: 10.1016/j.path.2023.06.006. Epub 2023 Aug 1.

Authors

Erica Y Kao¹, Eleanor Y Chen²

Affiliations

¹ Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Drive, Building 3600, 4th Floor, Room 447-6, San Antonio, TX 78234, USA.
² Department of Laboratory Medicine and Pathology, University of Washington, 1959 Northeast Pacific Street, Box 357705, HSB Room K072A, Seattle, WA 98195-7705, USA. Electronic address: eleanor2@uw.edu.

PMID: 38278609
DOI: 10.1016/j.path.2023.06.006

Abstract

Calcified chondroid mesenchymal neoplasms (CCMN) represent a morphologic spectrum of related tumors. Historically, chondroid matrix or chondroblastoma-like features have been described in soft tissue chondroma, tenosynovial giant cell tumors (especially of the temporomandibular joint (TMJ) region), and in a subset of tophaceous pseudogout. Recently, these tumors have been found to share FN1-receptor tyrosine kinase (RTK) fusions. This review discusses the clinical, morphologic, immunohistochemical, and molecular genetic features of CCMN. The distinction from morphologic mimics is also discussed.

Keywords: Calcified chondroid mesenchymal neoplasm; Chondroblastoma-like soft tissue chondroma; Chondroid tenosynovial giant cell tumor; Tophaceous pseudogout / tumoral calcium pyrophosphate dihydrate crystal deposition disease.

Publication types

Review

MeSH terms

Chondrocalcinosis* / pathology
Humans
Soft Tissue Neoplasms* / diagnosis
Soft Tissue Neoplasms* / genetics
Soft Tissue Neoplasms* / pathology
Temporomandibular Joint / pathology