Oral Immunotherapy for Peanut Allergy in Children 1 to Less Than 4 Years of Age

NEJM Evid. 2023 Nov;2(11):EVIDoa2300145. doi: 10.1056/EVIDoa2300145. Epub 2023 Oct 23.

Abstract

Oral Immunotherapy for Peanut Allergy in ChildrenThis trial enrolled children 1 to <4 years of age who had allergic symptoms from peanut protein during screening. Participants received peanut allergen powder-dnfp (PTAH) or placebo for approximately 12 months; 73.5% of participants receiving PTAH tolerated a single dose of ≥600 mg peanut protein versus 6.3% of the placebo group.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Allergens
  • Arachis
  • Child
  • Desensitization, Immunologic
  • Double-Blind Method
  • Humans
  • Peanut Hypersensitivity* / prevention & control

Substances

  • Allergens