Live bacterial therapeutics for detection and treatment of colorectal cancer

Joanna Zhang; Jeff Hasty; Amir Zarrinpar

doi:10.1038/s41575-024-00901-8

Live bacterial therapeutics for detection and treatment of colorectal cancer

Nat Rev Gastroenterol Hepatol. 2024 May;21(5):295-296. doi: 10.1038/s41575-024-00901-8.

Authors

Joanna Zhang^{1

2

3}, Jeff Hasty^{1

2

3

4}, Amir Zarrinpar^{5

6

7

8

9}

Affiliations

¹ Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
² Biodynamics Laboratory, University of California, San Diego, La Jolla, CA, USA.
³ Synthetic Biology Institute, University of California, San Diego, La Jolla, CA, USA.
⁴ Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.
⁵ Synthetic Biology Institute, University of California, San Diego, La Jolla, CA, USA. azarrinpar@ucsd.edu.
⁶ Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA. azarrinpar@ucsd.edu.
⁷ Jennifer Moreno Department of Veterans Affairs, La Jolla, CA, USA. azarrinpar@ucsd.edu.
⁸ Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA. azarrinpar@ucsd.edu.
⁹ Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. azarrinpar@ucsd.edu.

Abstract

Live microorganisms can be manipulated and engineered for colorectal cancer detection and treatment through methods such as faecal microbiota transplantation, native bacteria engineering and synthetic circuit engineering. Although promising, substantial effort is required to translate these approaches for clinical use.

MeSH terms

Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / therapy
Gastrointestinal Microbiome
Humans
Probiotics / therapeutic use

Abstract

MeSH terms

Grants and funding