Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI

Laurel A Screven; Caroline B Pantazis; Katherine M Andersh; Samantha Hong; Dan Vitale; Erika Lara; Ray Yueh Ku; Peter Heutink; Jason Meyer; Kelley Faber; Kwangsik Nho; Andrew J Saykin; Tatiana M Foroud; Mike A Nalls; Cornelis Blauwendraat; Andrew Singleton; Priyanka S Narayan

doi:10.1016/j.neuron.2024.01.026

Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI

Neuron. 2024 Mar 6;112(5):694-697. doi: 10.1016/j.neuron.2024.01.026. Epub 2024 Feb 21.

Authors

Laurel A Screven¹, Caroline B Pantazis¹, Katherine M Andersh¹, Samantha Hong¹, Dan Vitale², Erika Lara¹, Ray Yueh Ku¹, Peter Heutink³, Jason Meyer⁴, Kelley Faber⁵, Kwangsik Nho⁶, Andrew J Saykin⁷, Tatiana M Foroud⁸, Mike A Nalls², Cornelis Blauwendraat⁹, Andrew Singleton⁹, Priyanka S Narayan¹⁰

Affiliations

¹ Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
² Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; DataTecnica LLC, Washington, DC, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
³ German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
⁴ Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
⁵ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
⁷ Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
⁸ Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
⁹ Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
¹⁰ Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: priyanka.narayan@nih.gov.

PMID: 38387456
DOI: 10.1016/j.neuron.2024.01.026

Abstract

The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from Alzheimer's Disease Neuroimaging Initiative participants. These lines are sex balanced, include common APOE genotypes, span disease stages, and are ancestrally diverse. Cell lines and characterization data will be shared openly.

Published by Elsevier Inc.

MeSH terms

Alzheimer Disease* / genetics
Cell Line
Humans
Induced Pluripotent Stem Cells*
Neuroimaging / methods