Challenges in management of Candida auris meningitis secondary to infected ventriculoperitoneal shunt - A case report

Indian J Med Microbiol. 2024 Mar-Apr:48:100555. doi: 10.1016/j.ijmmb.2024.100555. Epub 2024 Mar 8.

Abstract

Meningitis in patients with ventriculo-peritoneal shunt (VP shunt) caused by various species of Candida have been widely described in literature. However, reports describing Candida auris as a cause of meningitis is limited. In this case report we describe a case of multidrug resistant Candida auris meningitis secondary to VP shunt infection successfully treated with intrathecal amphotericin B deoxycholate and intravenous liposomal amphotericin B. This is the second case report of successful treatment of Candida auris meningitis from India. More literature regarding the use of intrathecal/intraventricular echinocandins including optimal dosing and duration of therapy is needed.

Keywords: Anti fungal susceptibility; Candida auris; Intrathecal caspofungin; Meningitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B* / administration & dosage
  • Amphotericin B* / therapeutic use
  • Antifungal Agents* / administration & dosage
  • Antifungal Agents* / therapeutic use
  • Candida auris
  • Candidiasis* / drug therapy
  • Candidiasis* / microbiology
  • Deoxycholic Acid* / therapeutic use
  • Drug Combinations
  • Drug Resistance, Multiple, Fungal
  • Female
  • Humans
  • India
  • Male
  • Meningitis, Fungal* / diagnosis
  • Meningitis, Fungal* / drug therapy
  • Meningitis, Fungal* / microbiology
  • Treatment Outcome
  • Ventriculoperitoneal Shunt* / adverse effects

Substances

  • Amphotericin B
  • Antifungal Agents
  • liposomal amphotericin B
  • Deoxycholic Acid
  • amphotericin B, deoxycholate drug combination
  • Drug Combinations