IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

Hiroki Hosoi; Shotaro Tabata; Hideki Kosako; Yoshikazu Hori; Tadashi Okamura; Yusuke Yamashita; Kota Fujimoto; Daiki Kajioka; Kentaro Suzuki; Motomi Osato; Gen Yamada; Takashi Sonoki

doi:10.1016/j.lrr.2024.100451

IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma

Leuk Res Rep. 2024 Feb 22:21:100451. doi: 10.1016/j.lrr.2024.100451. eCollection 2024.

Authors

Affiliations

¹ Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
² Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
³ Faculty of Life and Environmental Sciences, University of Yamanashi, Takeda 4-4-37, Kofu City, Yamanashi, Japan.
⁴ International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Abstract

IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, its functional properties have been unclear. We found that two mature B-cell lymphoma cell lines expressed IGLL5 mRNA with Cλ1 segment. JQ1 treatment resulted in down-expression of IGLL5, indicating that IGLL5 is controlled by SE. IGLL5 knockdown induced cell death with down-expression of MYC. Our results suggested that IGLL5 might have a role in survival of mature B-cell tumors and involvement in MYC expression. (100 words).

Keywords: Immunoglobulin lambda like polypeptide 5 (igll5); Mature b-cell lymphoma; Super-enhancer, SiRNA.