Padina boergesenii mediated synthesis of Se-ZnO bimetallic nanoparticles for effective anticancer activity

Abstract

Introduction: Evaluating the anticancer property of Padina boergesenii mediated bimetallic nanoparticles.

Methods: The present study focuses on synthesizing Se-ZnO bimetallic nanoparticles from an aqueous algal extract of brown algae Padina boergesenii.Synthesized Se-ZnO NPs were characterized by UV, FTIR, SEM-EDS and HRTEM for confirmation along with the anticancer activity by MTT assay.

Results: The UV gave an absorbance peak at 342 and 370 nm, and the FTIR showed functional groups involved in synthesizing Se-ZnO NPs. The TEM micrographs indicated the crystalline nature and confirmed the size of the Se-ZnO NPs to be at an average size of 26.14 nm. Anticancer efficacy against the MCF-7 breast and HepG2 (hepatoblastoma) cell lines were also demonstrated, attaining an IC₅₀ value of 67.9 µg and 74.9 µg/ml respectively, which caused 50% cell death.

Discussion: This work aims to highlight an effective method for delivering bioactive compounds extracted from brown algae and emphasize its future therapeutic prospects. The potential of Selenium-Zinc oxide nanoparticles is of great interest due to the biocompatibility and low toxicity aspects of selenium combined with the cost-effectiveness and sustainability of zinc metal. The presence of bioactive compounds contributed to the stability of the nanoparticles and acted as capping properties.

Keywords: MCF7 breast cancer cell line; Padina boergesenii; Se-ZnO nanoparticles; anticancer; green synthesis; hepatoblastoma cell lines.