Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

Tyree D Williams; Talia Adler; Lindsey Smokoff; Anmoldeep Kaur; Benjamin Rodriguez; Kavita Jyoti Prakash; Edib Redzematovic; Turner S Baker; Benjamin I Rapoport; Edward S Yoon; Douglas P Beall; Jonathan S Dordick; Reade A De Leacy

doi:10.2147/JPR.S437827

Bone Cements Used in Vertebral Augmentation: A State-of-the-art Narrative Review

J Pain Res. 2024 Mar 13:17:1029-1040. doi: 10.2147/JPR.S437827. eCollection 2024.

Authors

Tyree D Williams^{1

2

3}, Talia Adler^{2

4}, Lindsey Smokoff^{2

4}, Anmoldeep Kaur^{2

5}, Benjamin Rodriguez^{2

3

6}, Kavita Jyoti Prakash⁶, Edib Redzematovic², Turner S Baker^{2

3

7}, Benjamin I Rapoport^{2

3}, Edward S Yoon⁸, Douglas P Beall⁹, Jonathan S Dordick¹, Reade A De Leacy³

Affiliations

¹ Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
² Sinai BioDesign, Mount Sinai Medical System, New York, NY, USA.
³ Department of Neurosurgery, Mount Sinai Medical System, New York, NY, USA.
⁴ Columbia University School of General Studies, New York, NY, USA.
⁵ Department of Neuroscience, Smith College, Northampton, MA, USA.
⁶ Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁷ Department of Population Health Science & Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁸ Hospital for Special Surgery, New York, NY, USA.
⁹ Spine Fracture Institute, Oklahoma City, OK, USA.

Abstract

Vertebral compression fractures (VCFs) are common in osteoporotic patients, with a frequency projected to increase alongside a growing geriatric population. VCFs often result in debilitating back pain and decreased mobility. Cement augmentation, a minimally invasive surgical technique, is widely used to stabilize fractures and restore vertebral height. Acrylic-based cements and calcium phosphate cements are currently the two primary fill materials utilized for these procedures. Despite their effectiveness, acrylic bone cements and calcium phosphate cements have been associated with various intraoperative and postoperative incidents impacting VCF treatment. Over the past decade, discoveries in the field of biomedical engineering and material science have shown advancements toward addressing these limitations. This narrative review aims to assess the potential pitfalls and barriers of the various types of bone cements.

Keywords: bone cement; kyphoplasty; osteoporosis; vertebral augmentation; vertebral compression fractures; vertebroplasty.

Publication types

Review