Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy

Abstract

Malaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to the human pathophysiological response. Thus, complete elimination becomes one of the major health challenges. Although malaria vaccine(s) are available in the market, they still contain to cause high morbidity and mortality. Therefore, an approach for eradication is needed through the exploration of novel molecular targets by tracking the epidemiological changes the parasite adopts. This review focuses on the various novel molecular targets.

Keywords: Apicoplaste des globules rouges; Cibles moléculaires; Malaria; Molecular targets; New permeation pathway; Nouvelle voie de perméation; Paludisme; Plasmodium; Red blood cell apicoplast; Transporters; Transporteurs.