Reliability assessment of the OMERACT whole-body magnetic resonance imaging scoring system for juvenile idiopathic arthritis

Jyoti Panwar; Mirkamal Tolend; Eva Kirkhus; Arthur B Meyers; Bernadette Redd; Iwona Sudol-Szopinska; Nisha Varma; Emilio J Inarejos Clemente; Robert A Colbert; Jonathan Akikusa; Simone Appenzeller; John A Carrino; Nele Herregods; Kerri Highmore; Lennart Jans; Jacob L Jaremko; Thekla von Kalle; Marion A van Rossum; Dax G Rumsey; Hemalatha Srinivasalu; Jennifer Stimec; Shirley M Tse; Marinka Twilt; Nikolay Tzaribachev; Andrea S Doria

doi:10.1016/j.semarthrit.2024.152437

Reliability assessment of the OMERACT whole-body magnetic resonance imaging scoring system for juvenile idiopathic arthritis

Semin Arthritis Rheum. 2024 Jun:66:152437. doi: 10.1016/j.semarthrit.2024.152437. Epub 2024 Mar 16.

Authors

Jyoti Panwar¹, Mirkamal Tolend², Eva Kirkhus³, Arthur B Meyers⁴, Bernadette Redd⁵, Iwona Sudol-Szopinska⁶, Nisha Varma⁷, Emilio J Inarejos Clemente⁸, Robert A Colbert⁹, Jonathan Akikusa¹⁰, Simone Appenzeller¹¹, John A Carrino¹², Nele Herregods¹³, Kerri Highmore¹⁴, Lennart Jans¹³, Jacob L Jaremko¹⁵, Thekla von Kalle¹⁶, Marion A van Rossum¹⁷, Dax G Rumsey¹⁸, Hemalatha Srinivasalu¹⁹, Jennifer Stimec², Shirley M Tse²⁰, Marinka Twilt²¹, Nikolay Tzaribachev²², Andrea S Doria²³

Affiliations

¹ Department of Medical Imaging, The Tweed Hospital, Tweed Heads, NSW, Australia. Lumus Imaging, Brisbane, Queensland, Australia.
² Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, and Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
³ Department of Radiology, Oslo University Hospital, Oslo, Norway.
⁴ Department of Radiology, Cincinnati Children's Hospital, Cincinnati, OH, United States.
⁵ Department of Radiology, Clinical Center, NIH, Bethesda, Maryland, United States.
⁶ Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
⁷ Department of Medical Imaging, The Royal Children's Hospital, Murdoch Children's Research Institute and Department of Medical Imaging, Western Health, Melbourne, Australia.
⁸ Department of Radiology, Hospital Sant Joan de Deu, Barcelona, Spain.
⁹ Pediatric Translational Research Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States.
¹⁰ Rheumatology Service, Department of General Medicine, Royal Children's Hospital Melbourne, Australia.
¹¹ Department of Orthopedics, Rheumatology and Traumatology, School of Medical Science, University of Campinas, Campinas, Brazil.
¹² Department of Radiology, Hospital for Special Surgery, New York, United States.
¹³ Department of Radiology, Ghent University, Ghent, Belgium.
¹⁴ Department of Radiology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
¹⁵ Department of Radiology & Diagnostic Imaging, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada.
¹⁶ RadiologischesInstitut, Olga Hospital Klinikum, Stuttgart, Germany.
¹⁷ Amsterdam Rheumatology and Immunology Center, Reade, and Emma Children's Hospital Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
¹⁸ Division of Rheumatology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
¹⁹ Pediatric Translational Research Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States; Division of Rheumatology, Children's National Hospital and George Washington University School of Medicine, Washington, DC, United States.
²⁰ Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.
²¹ Department of Pediatrics, Section of Rheumatology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
²² Image Analysis Group, Bad Bramstedt, Germany.
²³ Department of Diagnostic Imaging, Research Institute, The Hospital for Sick Children, and Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. Electronic address: andrea.doria@sickkids.ca.

PMID: 38564998
DOI: 10.1016/j.semarthrit.2024.152437

Abstract

Inter-reader reliability of a new scoring system for evaluating joint inflammation and enthesitis in whole body MRI (WBMRI) in juvenile idiopathic arthritis was tested. The scoring system grades 732 item-region combinations of bone marrow and soft tissue changes for commonly involved joints and entheseal sites. Five radiologists rated 17 WBMRI scans through an online rating platform. Item-wise reliability was calculated for 117 items with non-zero scores in >10 % of readings. Interquartile ranges of the five-reader Kappa reliability coefficients were 0.58-0.73 (range: 0.36-0.88) for the joints, 0.65-0.81 (range: 0.39-0.95) for the entheses, and 0.62-0.75 (range: 0.60-0.76) for chronic nonbacterial osteomyelitis-like lesions.

Keywords: Children; Cno; Juvenile idiopathic arthritis; Omeract; Reliability; Scoring system; Whole body mri.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Arthritis, Juvenile* / diagnostic imaging
Child
Child, Preschool
Female
Humans
Joints / diagnostic imaging
Magnetic Resonance Imaging* / methods
Male
Reproducibility of Results
Severity of Illness Index
Whole Body Imaging* / methods