Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2-313.2K

Anali Ali Akbari; Aynaz Zarghampour; Nastaran Hashemzadeh; Salar Hemmati; Elaheh Rahimpour; Abolghasem Jouyban

doi:10.1016/j.pharma.2024.03.010

Solubility and thermodynamics of mesalazine in aqueous mixtures of poly ethylene glycol 200/600 at 293.2-313.2K

Ann Pharm Fr. 2024 Apr 3:S0003-4509(24)00045-2. doi: 10.1016/j.pharma.2024.03.010. Online ahead of print.

Authors

Anali Ali Akbari¹, Aynaz Zarghampour¹, Nastaran Hashemzadeh¹, Salar Hemmati¹, Elaheh Rahimpour², Abolghasem Jouyban³

Affiliations

¹ Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
² Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, 5165665811 Tabriz, Iran. Electronic address: rahimpour_e@yahoo.com.
³ Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Near East University, Po Box: 99138, North Cyprus, Mersin 10, Nicosia, Turkey.

PMID: 38579928
DOI: 10.1016/j.pharma.2024.03.010

Abstract

In this study, the solubility of mesalazine was investigated in binary solvent mixtures of poly ethylene glycols 200/600 and water at temperatures ranging from 293.2K to 313.2K. The solubility of mesalazine was determined using a shake-flask method, and its concentrations were measured using a UV-Vis spectrophotometer. The obtained solubility data were analyzed using mathematical models including the van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson models. The experimental data obtained for mesalazine dissolution encompassed various thermodynamic properties, including ΔG°, ΔH°, ΔS°, and TΔS°. These properties offer valuable insights into the energetic aspects of the dissolution process and were calculated based on the van't Hoff equation.

Keywords: Calculs mathématiques; Cosolvabilité; Cosolvency; Mathematical computations; Mesalasine; Mésalasine; Propriétés thermodynamiques; Thermodynamic properties.