Association of the AhR, ARNT, and AhRR gene polymorphisms and cord blood AhR levels with elevated cord blood IgE susceptibility in Taiwan mother-infant pairs: a nested case-control study

Ying-Chu Lin; Li-Hsuan Wang; Hui-Ju Wen; Chiu-Yueh Yang; Yung-Ling Lee; Ching-Chang Lee; Eing-Mei Tsai; Shau-Ku Huang; Yue-Liang Leon Guo

doi:10.1080/09603123.2024.2338896

Association of the AhR, ARNT, and AhRR gene polymorphisms and cord blood AhR levels with elevated cord blood IgE susceptibility in Taiwan mother-infant pairs: a nested case-control study

Int J Environ Health Res. 2024 Apr 8:1-11. doi: 10.1080/09603123.2024.2338896. Online ahead of print.

Authors

Ying-Chu Lin¹, Li-Hsuan Wang², Hui-Ju Wen³, Chiu-Yueh Yang⁴, Yung-Ling Lee⁵, Ching-Chang Lee⁶, Eing-Mei Tsai⁷, Shau-Ku Huang³, Yue-Liang Leon Guo⁸

Affiliations

¹ School of Dentistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
² Division of Molecular Diagnosis, Department of Clinical Laboratory, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
³ National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli County, Taiwan.
⁴ Department of Health Business Administration, Hungkuang University, Taichung, Taiwan.
⁵ Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
⁶ Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.
⁷ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁸ Department of Environmental and Occupational Medicine, College of Medicine, National Taiwan University (NTU) and NTU Hospital, Taipei, Taiwan.

PMID: 38590026
DOI: 10.1080/09603123.2024.2338896

Abstract

The roles of aryl hydrocarbon receptor (AhR), AhR-nuclear translocator (ARNT), and AhR repressor (AhRR) genes in the elevation of cord blood IgE (CbIgE) remained unclear. Our aims were to determine the polymorphisms of AhR, ARNT, and AhRR genes, cord blood AhR (CBAhR) level, and susceptibility to elevation of CbIgE. 206 infant-mother pairs with CbIgE>=0.35 IU/ml and 421 randomly selected controls recruited from our previous study. Genotyping was determined using TaqMan assays. Statistical analysis showed AhR rs2066853 (GG vs. AA+AG: adjusted OR (AOR)=1.5, 95%CI=1.10-2.31 and AOR=1.60, 95%CI=1.06-2.43, respectively) and the combination of AhR rs2066853 and maternal total IgE (mtIgE)>=100 IU/ml were significantly correlated with CbIgE>=0.35 IU/ml or CbIgE>=0.5 IU/ml. CBAhR in a random subsample and CbIgE levels were significantly higher in infants with rs2066853GG genotype. We suggest that infant AhR rs2066853 and their interactions with mtIgE>=100 IU/ml significantly correlate with elevated CbIgE, but AhRR and ARNT polymorphisms do not.

Keywords: AhR nuclear translocator (ARNT); AhR repressor (AhRR); Aryl hydrocarbon receptor (AhR); cord blood IgE; susceptibility.