Transforming Pharmaceutical Synthesis with Sein-E-B Nanocomposite Photocatalyst through 1,4-NAD(P)H Cofactor Regeneration and C-N Bond Activation

Ravindra K Shukla; Rajesh K Yadav; Vitthal L Gole; Rajat Singhal; Rehana Shahin; Shaifali Mishra; Satyam Singh; Kanchan Sharma; Jin-Ook Baeg; Gamal A El-Hiti; Krishna Kumar Yadav; Navneet Kumar Gupta

doi:10.1002/cbdv.202400329

Transforming Pharmaceutical Synthesis with Se_in-E-B Nanocomposite Photocatalyst through 1,4-NAD(P)H Cofactor Regeneration and C-N Bond Activation

Chem Biodivers. 2024 Apr 8:e202400329. doi: 10.1002/cbdv.202400329. Online ahead of print.

Authors

Affiliations

¹ Department of Chemistry and Environmental Science, Madan Mohan Malaviya University of Technology, Gorakhpur, U.P., 273010, India.
² Department of Chemical Engineering, Madan Mohan Malaviya University of Technology, Gorakhpur, 273010, U.P., India.
³ Centre for Sustainable Technologies, Indian Institute of Science, Gulmohar Marg, Mathikere, Bengaluru, 560012, India.
⁴ Artificial Photosynthesis Research group, Korea Research Institute of Chemical Technology, Yuseong-gu, Daejeon, 34114, Republic of Korea.
⁵ Department of Optometry, College of Applied, Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia.
⁶ Faculty of Science and Technology, Madhyanchal Professional University, Ratibad, Bhopal, 462044, India.
⁷ Environmental and Atmospheric Sciences Research Group, Scientific Research Center, Al-Ayen University, Thi-Qar, Nasiriyah, 64001, Iraq.

PMID: 38590163
DOI: 10.1002/cbdv.202400329

Abstract

The need for sunlight chemical renewal and contemporary organic transformation has fostered the advancement of environmentally friendly photocatalytic techniques. For the first time, we report on the novel crafting of a bright future with selenium-infused Eosin-B (Se_in-E-B) nanocomposite photocatalysts in this work. The Se_in-E-B nanocomposite materials were created using a hydrothermal process for solar chemical regeneration and organic transformation under visible light. The synthesized samples were subjected to UV-DRS-visible spectroscopy, FT-IR, SEM, EDX, EIS and XRD analysis. The energy band gap of the Se_in-E-B nanocomposite photocatalyst was measured using UV-DRS, and the result was around 2.06 eV. to investigate the generated Se_in-E-B catalytic activity as a nanocomposite for 1,4-NADH/NADPH re-formation and C-N bond activation. This novel photocatalyst offers a promising alternative for the regeneration of solar chemicals and C-N bond creation between pyrrole and aryl halides.

Keywords: 1,4-NADH/NADPH regeneration; C−N bond formation; Sein-E-B nanocomposite photocatalysts; Solar light.

Abstract

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