Efficacy of Aloe Vera, Amlexanox (5%), and Triamcinolone Acetonide (0.1%) in the Management of Oral Lichen Planus

Manpreet Kaur; Prerna Gulati; Sugandha Verma; Parul Khare; Ruchi Garg; Jahnobi Dutta; Kumuda Rao

doi:10.4103/jpbs.jpbs_416_23

Efficacy of Aloe Vera, Amlexanox (5%), and Triamcinolone Acetonide (0.1%) in the Management of Oral Lichen Planus

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S133-S135. doi: 10.4103/jpbs.jpbs_416_23. Epub 2023 Dec 20.

Authors

Manpreet Kaur¹, Prerna Gulati², Sugandha Verma³, Parul Khare⁴, Ruchi Garg⁵, Jahnobi Dutta⁶, Kumuda Rao⁷

Affiliations

¹ Associate Professor, Department of Oral Pathology, Maharishi Markandeshwar College of Dental Sciences and Research (Deemed to be University) Mullana, Haryana, India.
² Professor and Head, Department of Public Health Dentistry, Guru Nanak Dev Dental College and Research Institute, Sunam, Punjab, India.
³ Senior Resident, Department of Oral Medicine and Radiology, Dental College, Rajendra Institute of Medical Sciences, Ranchi, India.
⁴ Assistant Professor, Department of Oral & Maxillofacial Pathology & Oral Microbiology, School of Dental Sciences, Sharda University, Greater Noida, India.
⁵ Associate Professor, Department of Public Health Dentistry, Swami Devi Dyal Hospital and Dental College, Barwala, Panchkula, Haryana, India.
⁶ Reader, Department of Oral and Maxillofacial Pathology, Government Dental College, Dibrugarh, Assam, India.
⁷ Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Department of Oral Medicine and Radiology, Deralakatte, Mangalore, Karnataka, India.

Abstract

Objective: This research assessed the efficiencies of aloe vera, 0.1% triamcinolone acetonide, and 5% amlexanox in the management of OLP.

Materials and methods: A total of 120 participants diagnosed with oral lichen planus (OLP) were equally divided into three groups and treated with: aloe vera, (Group A), 0.1% triamcinolone acetonide (Group B), and 5% amlexanox (Group C) topical medicaments. The patients were evaluated for pain, using the visual analogue scale (VAS). They were also evaluated for ulcerative lesion type and erosive area on days 1, 7, and 15 of the study.

Results: There was a statistically considerable decrease in the VAS pain scale score, reduction in the erosive area on buccal mucosa, and healing of ulcer from day 1^st to 15^th day with all three tested drugs.

Conclusion: All drugs used in this study; aloe vera, triamcinolone acetonide, and amlexanox were effective in treating OLP patients.

Keywords: Aloe vera; erosive; mucosa; oral lichen planus; visual analogue scale.