Efficacy of Various Herbal Preparations Against Oral Candida: A Lab-Based Study

Prashant A Karni; Aparna Muraleedharan; Srikala Bhandary; Sheetal Mujoo; Anuj Paul Maini; Mudita Chaturvedi

doi:10.4103/jpbs.jpbs_486_23

Efficacy of Various Herbal Preparations Against Oral Candida: A Lab-Based Study

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S265-S267. doi: 10.4103/jpbs.jpbs_486_23. Epub 2024 Feb 29.

Authors

Prashant A Karni¹, Aparna Muraleedharan², Srikala Bhandary³, Sheetal Mujoo⁴, Anuj Paul Maini⁵, Mudita Chaturvedi⁶

Affiliations

¹ Department of Prosthodontics and Crown and Bridge, KAHER'S KLE VK Institute of Dental Sciences, Belagavi, Karnataka, India.
² Department of Oral Medicine and Radiology, Al Azhar Dental College, Thodupuzha, Kerala, India.
³ Department of Pediatric and Preventive Dentistry, AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.
⁴ Department of Oral Medicine and Radiology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
⁵ Department of Oral Medicine and Radiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.
⁶ Department of Oral and Maxillofacial Pathology, Private Practitioner, Bhopal, Madhya Pradesh, India.

Abstract

Aim: This research was done to analyze the effectiveness related to herbal chemicals in tackling candidiasis.

Materials and methods: Grounded and ethanol-extracted residues of plants like Avicennia marina, Fagonia indica, Portulaca oleracea, Lawsania inermis, Ziziphus spina, Asphodelus tenuifolius, and Salvadora persica were used in the study. The extract was used against candida species, after which the antibacterial as well as cytotoxicity toward the former were evaluated.

Results: L. inermis and P. oleracea with minimal inhibitory concentration of approx. 10 cenmL had an increased activity against candida species. The preparations of these plants acted against Candida albicans during its stages related to pathogenesis during biofilm production. Superadded infections like in case of bacterial infections along with candida can be difficult to cure. On human RBCs, these plant preparations had no toxicity at their minimum inhibitory concentration level.

Conclusion: We concluded that, as far as being anti-candida and acting against MDR bacterial infections, preparations of plants were effective as an alternative to allopathic drugs.

Keywords: Antimicrobial; candida; herbal preparations.